Motif ID: STAT5{A,B}.p2

Z-value: 1.377


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Achr17_+_404404810.881.8e-10Click!
STAT5Bchr17_-_40428311-0.328.0e-02Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_142829169 11.573 NM_002652
 PIP
prolactin-induced protein
chr11_+_73357222 10.132 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_-_44860798 6.869 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_35168558 6.039 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chrY_+_2709596 5.502 NM_001008
 RPS4Y1
ribosomal protein S4, Y-linked 1
chrY_+_2709630 5.045 RPS4Y1
ribosomal protein S4, Y-linked 1
chr16_-_53737713 3.738 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr18_-_24765178 3.508 NM_031422
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr19_+_44645728 3.135 ZNF234
zinc finger protein 234
chr19_+_58816714 2.931 ERVK3-1
endogenous retrovirus group K3, member 1
chr19_+_58281049 2.895 ZNF586
zinc finger protein 586
chr16_-_3085541 2.825 NM_001103175
 CCDC64B
coiled-coil domain containing 64B
chr19_+_58816757 2.649 ERVK3-1
endogenous retrovirus group K3, member 1
chr19_+_44716683 2.486 NM_182490
 ZNF227
zinc finger protein 227
chr3_+_130745693 2.391 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr8_-_144699621 2.292 TSTA3
tissue specific transplantation antigen P35B
chr5_+_178450775 2.285 NM_001136116
 ZNF879
zinc finger protein 879
chr19_+_58280996 2.270 NM_001077426
NM_001204814
NM_017652
 ZNF586


zinc finger protein 586


chr12_+_133656984 2.207 NM_003440
 ZNF140
zinc finger protein 140
chr19_-_40596781 2.177 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr19_-_45004482 2.091 NM_013256
 ZNF180
zinc finger protein 180
chr19_-_44809126 2.053 NM_004234
 ZNF235
zinc finger protein 235
chr19_+_44556163 2.053 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_35225095 2.021 ZNF181
zinc finger protein 181
chr12_+_133657439 1.962 ZNF140
zinc finger protein 140
chr12_+_133657478 1.852 ZNF140
zinc finger protein 140
chr4_-_16085309 1.836 PROM1
prominin 1
chr4_-_16085666 1.743 PROM1
prominin 1
chr19_+_58341661 1.740 NM_001204818
 LOC100293516
zinc finger protein
chr2_-_27886443 1.722 NM_014860
 SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr19_+_58258160 1.705 NM_173632
 ZNF776
zinc finger protein 776
chr8_-_144699695 1.668 TSTA3
tissue specific transplantation antigen P35B
chr2_+_88991166 1.660 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr6_-_29527477 1.632 UBD
ubiquitin D
chr19_+_54024176 1.555 NM_018555
 ZNF331
zinc finger protein 331
chr2_-_63815761 1.538 NM_015910
 WDPCP
WD repeat containing planar cell polarity effector
chr2_-_241500459 1.505 ANKMY1
ankyrin repeat and MYND domain containing 1
chr19_-_58326280 1.502 NM_024762
 ZNF552
zinc finger protein 552
chr19_-_44439410 1.484 NM_003425
 ZNF45
zinc finger protein 45
chr9_+_104161118 1.467 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chr6_-_27440459 1.462 NM_007149
 ZNF184
zinc finger protein 184
chr11_+_65268313 1.426 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr8_+_110346549 1.395 NM_001193557
NM_020189
 ENY2

enhancer of yellow 2 homolog (Drosophila)

chr1_+_149871154 1.395 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr16_+_53468373 1.383 RBL2
retinoblastoma-like 2 (p130)
chr4_+_86396251 1.343 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr19_+_39882018 1.340 MED29
mediator complex subunit 29
chr19_+_44669214 1.318 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chr1_-_54518915 1.312 TMEM59
transmembrane protein 59
chr14_-_20881577 1.308 NM_007110
 TEP1
telomerase-associated protein 1
chr1_-_54518886 1.278 TMEM59
transmembrane protein 59
chr1_-_54518790 1.269 TMEM59
transmembrane protein 59
chr11_+_63137260 1.265 NM_080866
 SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr2_+_95831176 1.262 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr19_-_50528683 1.227 NM_001025778
NM_016440
 VRK3

vaccinia related kinase 3

chr19_-_37019169 1.223 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr19_+_44529493 1.216 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_+_50529276 1.202 ZNF473
zinc finger protein 473
chr16_-_279338 1.175 NM_018032
NM_201412
 LUC7L

LUC7-like (S. cerevisiae)

chr19_+_39881950 1.160 NM_017592
 MED29
mediator complex subunit 29
chr19_+_35225479 1.140 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr3_+_183903970 1.130 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr19_+_17416476 1.126 NM_023937
 MRPL34
mitochondrial ribosomal protein L34
chr19_-_38085646 1.119 NM_016536
 ZNF571
zinc finger protein 571
chr1_+_40997290 1.109 ZNF684
zinc finger protein 684
chr2_-_63815581 1.109 WDPCP
WD repeat containing planar cell polarity effector
chr8_-_56685869 1.086 NM_152417
 TMEM68
transmembrane protein 68
chr16_+_53468406 1.078 RBL2
retinoblastoma-like 2 (p130)
chr18_-_53071225 1.071 NM_001243232
 TCF4
transcription factor 4
chr19_-_36980758 1.069 ZNF566
zinc finger protein 566
chr19_+_36209125 1.064 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_+_58144510 1.056 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr19_-_37406918 1.036 NM_001171979
 ZNF829
zinc finger protein 829
chr2_+_219135114 1.034 NM_001077399
NM_015488
 PNKD

paroxysmal nonkinesigenic dyskinesia

chr3_+_183903862 1.027 NM_018358
 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr19_+_44617510 1.016 NM_013362
 ZNF225
zinc finger protein 225
chr1_+_153631144 1.014 NM_012437
 SNAPIN
SNAP-associated protein
chr1_+_153631193 0.997 SNAPIN
SNAP-associated protein
chr19_-_56904869 0.996 NM_144690
 ZNF582
zinc finger protein 582
chr2_-_241500167 0.991 ANKMY1
ankyrin repeat and MYND domain containing 1
chr17_-_47492216 0.988 NM_002634
 PHB
prohibitin
chr11_-_72504643 0.975 NM_006645
 STARD10
StAR-related lipid transfer (START) domain containing 10
chr4_+_130017281 0.961 NM_001099783
 C4orf33
chromosome 4 open reading frame 33
chr5_-_111093251 0.946 NM_001142479
NM_001142480
NM_001142478
 C5orf13


chromosome 5 open reading frame 13


chr19_+_58258189 0.928 ZNF776
zinc finger protein 776
chr16_+_53468362 0.927 RBL2
retinoblastoma-like 2 (p130)
chr1_-_54519050 0.923 NM_004872
 TMEM59
transmembrane protein 59
chr2_-_217540722 0.922 IGFBP5
insulin-like growth factor binding protein 5
chr12_+_102271082 0.918 NM_018370
 DRAM1
DNA-damage regulated autophagy modulator 1
chr11_+_36616039 0.918 NM_138787
 C11orf74
chromosome 11 open reading frame 74
chr1_-_120935893 0.908 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr19_-_7990974 0.899 NM_206833
 CTXN1
cortexin 1
chr13_+_115079943 0.886 NM_001164144
NM_001164145
NM_032436
 CHAMP1


chromosome alignment maintaining phosphoprotein 1


chr19_+_50529294 0.878 ZNF473
zinc finger protein 473
chr19_+_44331443 0.874 NM_181845
 ZNF283
zinc finger protein 283
chr19_+_56652689 0.859 ZNF444
zinc finger protein 444
chr19_-_36980336 0.846 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr16_+_53468390 0.812 RBL2
retinoblastoma-like 2 (p130)
chr3_-_113775363 0.807 NM_020817
 KIAA1407
KIAA1407
chr2_+_44001177 0.806 NM_001193464
NM_015522
NM_016008
 DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr19_+_58920118 0.803 ZNF584
zinc finger protein 584
chr19_+_44645708 0.789 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr16_+_53468344 0.789 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr6_+_139094656 0.772 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr19_-_35264091 0.770 NM_001007248
 ZNF599
zinc finger protein 599
chr20_-_48530275 0.767 NM_001135773
 SPATA2
spermatogenesis associated 2
chr8_-_144699716 0.763 NM_003313
 TSTA3
tissue specific transplantation antigen P35B
chr20_-_18477811 0.763 NM_006606
 RBBP9
retinoblastoma binding protein 9
chr22_-_38902281 0.743 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr7_+_99102272 0.740 NM_145102
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr19_+_36208917 0.740 NM_014727
 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr17_-_5322982 0.718 NM_002532
 NUP88
nucleoporin 88kDa
chr19_+_45909868 0.690 CD3EAP
CD3e molecule, epsilon associated protein
chr1_+_40997232 0.673 NM_152373
 ZNF684
zinc finger protein 684
chr19_-_50528627 0.655 VRK3
vaccinia related kinase 3
chr19_-_58514136 0.654 ZNF606
zinc finger protein 606
chr7_+_142960588 0.650 GSTK1
glutathione S-transferase kappa 1
chr15_+_22833394 0.648 NM_001102610
NM_052903
 TUBGCP5

tubulin, gamma complex associated protein 5

chr1_-_120935943 0.643 NM_001004340
NM_001017986
NM_001244910
 FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr5_-_145562068 0.637 LARS
leucyl-tRNA synthetase
chr19_+_37709068 0.629 ZNF383
zinc finger protein 383
chr8_+_8559665 0.624 NM_194284
 CLDN23
claudin 23
chr17_-_80023679 0.620 NM_022156
 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chrX_-_154250769 0.619 NM_000132
 F8
coagulation factor VIII, procoagulant component
chr11_+_2421983 0.618 TSSC4
tumor suppressing subtransferable candidate 4
chr8_+_17780351 0.615 NM_006197
 PCM1
pericentriolar material 1
chr6_-_83903632 0.611 NM_001199917
 PGM3
phosphoglucomutase 3
chr2_-_219134865 0.608 NM_001087
 AAMP
angio-associated, migratory cell protein
chr19_+_56652529 0.606 NM_001253792
NM_018337
 ZNF444

zinc finger protein 444

chr19_+_50529211 0.597 NM_001006656
NM_015428
 ZNF473

zinc finger protein 473

chr14_-_70883680 0.589 NM_001202547
NM_001202548
NM_001202549
NM_018373
 SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr19_+_58987751 0.581 NM_017908
 ZNF446
zinc finger protein 446
chr10_+_93558068 0.578 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr15_+_66874506 0.577


chr10_-_62493077 0.574 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_-_129402753 0.568 NM_017666
 ZNF280C
zinc finger protein 280C
chr19_+_44764032 0.567 NM_001207005
NM_181756
 ZNF233

zinc finger protein 233

chr12_-_133532847 0.562 NM_183238
NM_001164715
 ZNF605

zinc finger protein 605

chr5_+_140247767 0.561 NM_018902
NM_031861
 PCDHA11

protocadherin alpha 11

chr5_+_140261792 0.560 NM_018904
NM_031865
 PCDHA13

protocadherin alpha 13

chr4_+_25378816 0.551 NM_013367
 ANAPC4
anaphase promoting complex subunit 4
chr11_-_61124223 0.549 NM_001161452
 CYBASC3
cytochrome b, ascorbate dependent 3
chr19_+_54041332 0.546 NM_001079906
NM_001253798
NM_001253799
 ZNF331


zinc finger protein 331


chr7_+_142985307 0.545 NM_032982
NM_032983
 CASP2

caspase 2, apoptosis-related cysteine peptidase

chr17_-_80023514 0.538 DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr13_+_52436116 0.535 NM_031290
 CCDC70
coiled-coil domain containing 70
chr10_-_131909061 0.528 LOC387723
uncharacterized LOC387723
chr12_-_46384346 0.525 SCAF11
SR-related CTD-associated factor 11
chr12_-_46384208 0.519 SCAF11
SR-related CTD-associated factor 11
chr1_+_205236591 0.519 TMCC2
transmembrane and coiled-coil domain family 2
chr7_+_99102601 0.515 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr17_-_5322870 0.511 NUP88
nucleoporin 88kDa
chr6_-_32805819 0.505 TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr19_+_34895268 0.502 NM_032346
 PDCD2L
programmed cell death 2-like
chr6_+_88182704 0.491 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr5_-_145562214 0.488 LARS
leucyl-tRNA synthetase
chr19_-_58220535 0.488 NM_001085384
 ZNF154
zinc finger protein 154
chr19_-_50528576 0.478 VRK3
vaccinia related kinase 3
chr5_-_145562235 0.473 NM_020117
 LARS
leucyl-tRNA synthetase
chr19_+_37341259 0.471 NM_003419
 ZNF345
zinc finger protein 345
chr8_-_146012653 0.465 NM_030580
 ZNF34
zinc finger protein 34
chr19_+_58095507 0.461 NM_001010879
 ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr19_+_58920007 0.453 NM_173548
 ZNF584
zinc finger protein 584
chr7_+_99102572 0.452 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr15_-_83735892 0.452 BTBD1
BTB (POZ) domain containing 1
chr19_+_58331067 0.450 LOC100293516
zinc finger protein
chr19_+_57831824 0.448 NM_213598
 ZNF543
zinc finger protein 543
chr19_+_17530841 0.443 FAM125A
family with sequence similarity 125, member A
chr2_-_219134795 0.437 AAMP
angio-associated, migratory cell protein
chr2_+_172290796 0.433 DCAF17
DDB1 and CUL4 associated factor 17
chr16_+_2802656 0.428 SRRM2
serine/arginine repetitive matrix 2
chr1_+_87794150 0.426 NM_006769
 LMO4
LIM domain only 4
chr2_-_238499317 0.425 RAB17
RAB17, member RAS oncogene family
chr10_+_93558182 0.421 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr9_-_130186491 0.419


chr19_+_58361180 0.413 NM_001204817
NM_032828
 ZNF587

zinc finger protein 587

chr11_+_71640088 0.413 RNF121
ring finger protein 121
chr12_-_46384365 0.403 NM_004719
 SCAF11
SR-related CTD-associated factor 11
chrX_-_154563735 0.399 NM_001289
 CLIC2
chloride intracellular channel 2
chr17_+_32582295 0.397 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr1_-_3773620 0.396 CEP104
centrosomal protein 104kDa
chr1_-_3773760 0.394 NM_014704
 CEP104
centrosomal protein 104kDa
chr20_+_34824379 0.390 C20orf4
chromosome 20 open reading frame 4
chr12_-_22697439 0.385 NM_014802
 KIAA0528
KIAA0528
chrX_+_105412297 0.384 NM_001171020
NM_152423
 MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr5_-_10249997 0.378 NM_199133
 FAM173B
family with sequence similarity 173, member B
chr11_-_125773086 0.367 NM_031307
 PUS3
pseudouridylate synthase 3
chr1_+_220921576 0.365 NM_017898
 MARC2
mitochondrial amidoxime reducing component 2
chr11_-_49229994 0.362 NM_001014986
NM_001193471
NM_001193472
NM_001193473
NM_004476
 FOLH1




folate hydrolase (prostate-specific membrane antigen) 1




chr19_+_44507076 0.360 NM_006300
 ZNF230
zinc finger protein 230
chr19_+_37341724 0.356 NM_001242472
NM_001242474
 ZNF345

zinc finger protein 345

chr6_+_88182624 0.349 NM_001168398
NM_006416
 SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr19_-_37407079 0.348 NM_001037232
 ZNF829
zinc finger protein 829
chr17_-_33700619 0.345 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
 SLFN11




schlafen family member 11




chr19_-_44905754 0.345 NM_152354
 ZNF285
ZFP112
zinc finger protein 285
zinc finger protein 112 homolog (mouse)
chr11_+_67374322 0.343 NM_001166102
NM_007103
 NDUFV1

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

chr19_+_17378264 0.340 BABAM1
BRISC and BRCA1 A complex member 1
chr5_-_179498995 0.339 NM_018434
 RNF130
ring finger protein 130
chr1_+_179051111 0.338 NM_022371
 TOR3A
torsin family 3, member A
chr5_+_145317297 0.337 SH3RF2
SH3 domain containing ring finger 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.52 4.08e-12 GO:0006355 regulation of transcription, DNA-dependent
2.39 1.32e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.35 1.91e-11 GO:0010556 regulation of macromolecule biosynthetic process
2.42 3.25e-11 GO:0051252 regulation of RNA metabolic process
2.24 8.86e-11 GO:0009889 regulation of biosynthetic process
2.24 1.36e-10 GO:0031326 regulation of cellular biosynthetic process
2.23 8.49e-10 GO:0010468 regulation of gene expression
2.16 3.07e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.12 5.54e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.85 1.73e-06 GO:0060255 regulation of macromolecule metabolic process
1.81 1.88e-06 GO:0031323 regulation of cellular metabolic process
1.81 2.09e-06 GO:0080090 regulation of primary metabolic process
1.69 2.68e-05 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 7.19e-10 GO:0005634 nucleus
1.41 4.20e-09 GO:0043231 intracellular membrane-bounded organelle
1.41 4.72e-09 GO:0043227 membrane-bounded organelle
1.34 1.09e-07 GO:0043229 intracellular organelle
1.33 1.32e-07 GO:0043226 organelle
1.24 7.07e-06 GO:0044424 intracellular part
1.23 1.33e-05 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.66 7.43e-15 GO:0008270 zinc ion binding
2.46 1.22e-13 GO:0046914 transition metal ion binding
2.40 1.12e-12 GO:0003677 DNA binding
1.94 3.48e-09 GO:0003676 nucleic acid binding
1.82 4.33e-09 GO:0043169 cation binding
1.81 5.05e-09 GO:0043167 ion binding
1.82 5.19e-09 GO:0046872 metal ion binding